
Diabetic neuropathy (DN) represents a common, disabling and, until recently, largely neglected problem affecting approximately 50% of patients with diabetes at some point. According to the International Diabetes Federation, 425 million people world-wide aged 20 years had diabetes in 2017, and this number is expected to increase to 629 million by 2045. Approximately one in 3 people with diabetes experience painful diabetic neuropathy (PDN).